Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, numbness or tingling in the hands, feet, or lips, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, continuing ringing or buzzing or other unexplained noise in the ears, difficulty having a bowel movement (stool), feeling of constant movement of self or surroundings, increased sensitivity of the skin to sunlight, loss in sexual ability, desire, drive, or performance, redness or other discoloration of the skin. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. respect of any healthcare matters. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Mayo Clinic Staff. HNE at the higher of two doses extended TMV slowing to at least 24 hours when given with CFTRinh172 (Figure 5C). Cough and angiotensin II receptor antagonists: cause or confounding?" Keep from freezing. The optimum solution should not give you a bigger problem than you started with. pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting; swelling, weight gain, feeling short of breath, urinating less than usual or not at all; or. not moderated or reviewed by doctors and so you should not rely on opinions or advice given by other users in It is known to inhibit TGF- signaling, independent of its receptor-blocking action (2326). Your doctor may adjust your dose as needed. Mucus can come from the stomach (because the throat is close to the digestive tract) and from the sinuses. Avoid alcoholic beverages until you have discussed their use with your doctor. Your body is always producing mucus. The authors acknowledge Michael Myerburg for kindly providing the airway surface liquid volume-measurement, meniscus-scanning software; Brian Button for helping to establish the percentage mucus solid measurements; and Siddarth Rawal and Ashutosh Agarwal for their help using an Epilog Mini 30W laser to cut precise tissue meshes for lifting mucus off the cultures. You may report side effects to the FDA at 1-800-FDA-1088. If you have a persistent cough, you likely have mucus in your chest. The cough continued in this patient for the 2-week duration of losartan treatment; however, 1 week after substitution of losartan with enalapril (22.5 mg/d),the cough resolved completely. Throat mucus is the phlegm that lingers at the base of our throats when we are sick, but it also affects heavy smokers and those suffering from allergies causing sore throat Losartan significantly attenuated this effect, measured 4 hours after the first measurements (or 8 hours after initial challenge with CFTRinh172 plus HNE). And while their mechanism of action is slightly different. Furthermore, basolateral addition of TGF-1 (10 ng/ml) for 24 hours reduced apical potassium currents (Figure E4G) and ovine LRRC26 mRNA (Figure E4H). It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Federal government websites often end in .gov or .mil. b?uic. Avoid foods that can cause acid reflux. Heat helps break up and release mucus, so using heat on the face will provide comfort. Light gray areas in A, D, and E indicate statistically significant differences of time points compared with baseline, and dark gray areas indicate statistically significant differences of the same time points between different treatments using two-way ANOVA of repeated measures followed by Sidak multiple comparison test. Moexipril. ACE inhibitors lower blood pressure by blocking angiotensin-converting enzyme. This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. A lower blood pressure will increase the supply Even after the drug is stopped, the cough can linger for months until all the kinins eventually find their way out of the lungs. Blocking ACE (by taking an ACE inhibitor) allows bradykinin and substance P to build up in the lungs, which can lead to coughing. http://www.wikihow.com/Get-Rid-of-Mucus/, last accessed March 17, 2016. Do not use if you are pregnant. You should check with your doctor before changing your diet. Before Hoarseness A sensation of a lump in your throat A sore throat without an infection An allergy or virus could cause chronic mucus production. Along with its needed effects, a medicine may cause some unwanted effects. Moisture in the air can help keep your mucus thin. In extremely rare cases, losartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to potential kidney failure. Support Healthy Stomach Acid, Check out Dr. Berg's Digest Formula (with Betaine HCL and ACV). Correspondence and requests for reprints should be addressed to Matthias Salathe, Department of Internal Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, 4032 Delp, MS 1022, Kansas City, KS 66160. Figure 7. Available for Android and iOS devices. For non-prescription products, read the label or package ingredients carefully. Electrolyte imbalances (eg, high or low potassium or sodium in the body)Use with caution. The median age of predicted survival of these patients has improved to >40 years in the United States; however, patients still die from respiratory failure. Sign Up for the Latest Health News and Tips, Home General Health How to Reduce Mucus in the Throat. Airway inflammation contributes to mucociliary dysfunction and thus remains an important but unaddressed therapeutic target in CF. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with losartan, especially: aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. As a result, losartan relaxes the blood vessels. All information is observation-only, does not establish causal relationship, and has not been supported by scientific studies or clinical trials unless otherwise stated. If you are a Mayo Clinic patient, this could Thank you for clarying. Medications that affect angiotensin converting enzyme like Losartan have the potential to do this. It seems reasonable to a Losartan is an angiotensin II receptor blocker (ARB). Expanding on a validated and published nongenetic, CF-like sheep model, ewes inhaled CFTRinh172 and neutrophil elastase for 3 days, which resulted in prolonged tracheal mucus velocity reduction, mucus hyperconcentration, and increased TGF-1. Losartans effect is not mediated by angiotensin II receptor blocker in fully differentiated homozygous F508del cells. Methods for airway aerosol challenges and tracheal mucus velocity (TMV) have previously been published (2931). Based on these findings, we started clinical trials to test the effect of oral losartan in patients with CF (NCT03206788 and NCT03435939). Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Sheep were conscious and intubated during the course of the study. I recall my doctor prescribing Tessalon Perles when I suffered from bronchitis and it worked well. The exact mechanism by which losartan blocks TGF- signaling is unknown, although as shown in this study, activation of PPAR- might be involved (5355). Egton Medical Information Systems Limited. The medication is used to treat high blood pressure . Cough is an adverse event associated with the angiotensin-converting enzyme (AA inhibitor drugs. However, AT1R is not expressed in airway epithelia, and EXP3179 does not block the receptor. information is beneficial, we may combine your email and website usage information with This content does not have an Arabic version. Advertising revenue supports our not-for-profit mission. Resolution of ACE inhibitor cough: changes in subjective cough and responses to inhaled capsaicin, intradermal bradykinin and substance-P. [Clinical trials of ACE inhibitors and ARB for treatment of patients with hypertension, heart failure, and diabetic nephropathy in Japan--special reference to the dosage schedule and adverse effects]. We deduce that the rapid response in mucus clearance seems to rely on BK potentiation, whereas the more long-term response relies on replenishing cellular LRRC26. Heading South for the Winter? Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. (F) Same experiment as in B measuring mucus solids as described in Methods. Using this medicine with any of the following medicines is not recommended. I just thought it was a summer cold. Neutrophilic inflammation (elastase) reduces LRRC26 (leucine rich repeat containing 26) in vivo in patients with cystic fibrosis (CF) and TGF-1 (transforming growth factor 1)mediated LRRC26 reduction and large-conductance Ca2+-activated and voltage-dependent K+ (BK) channel dysfunction are ameliorated by losartan in fully differentiated homozygous F508del cells. However, the dose is usually not more than 50 mg per day. This model system also lends itself to test multiple interventions measuring multiple outcomes including mucus velocity, mucus concentration, and airway inflammation. Mucus thinners. Several large independent clinical studies have demonstrated that TGF-1 polymorphisms in CF are associated with worse lung function (8, 41). If we combine this information with your protected Version: 13.01. amlodipine, lisinopril, metoprolol, furosemide, hydrochlorothiazide, atenolol, ramipril, enalapril, captopril, irbesartan. There are a variety of conditions that can cause these symptoms, ranging from minor. Mayo Clinic Staff. If you mainly cough during the spring, summer and/or fall, an allergy-related cough is likely. I am almost 52 years old and in relatively good health. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. eCollection 2016. 1. Would you like email updates of new search results? Repeat a few times per session and again a few times per day. 3 0 obj Taking a hot shower and inhaling the steam. Airway mucus function and dysfunction. Can I give a small dose of this medicine to my child? Below are some tips to get rid of mucus from your throat*. Chronic mucus production in your throat can worsen at night, and you may notice other symptoms such as: An allergy or virus could cause chronic mucus production. We also evaluated these effects in vivo using CFTR inhibitors and neutrophil elastase to create CF-like, inflammation-associated mucociliary dysfunction in sheep, expanding on a previously validated nongenetic model of CF (11). Further investigations into this area will be needed. Losartan is the one about which he hears the least complaints from patients. You can learn more about how we ensure our content is accurate and current by reading our. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Using a Neti Pot One-way ANOVA followed by Holm-Sidak after passing Shapiro-Wilk normality test. Mayo Clinic does not endorse companies or products. CD45 is a marker of leukocytes and thus indirectly of neutrophil elastase (Figure 1A). n=10 experiments from a total of five different CF lungs. Your doctor may recommend medication such as: Your doctor may also suggest some self-care steps you can take to help reduce mucus, such as: Mucus is produced by the lower airways in response to inflammation. To make sure this medicine is safe for you, tell your doctor if you have: an electrolyte imbalance (such as low levels of potassium in your blood); or. (B) Change in airway surface liquid (ASL) volume (ASL volume) estimated by meniscus scanning in CF bronchial epithelial cells. You should not use this medication if you are allergic to losartan. n=12 from three different CF lungs. (D) Same experiment as in B but measuring CBF. Inhaled losartan partially affected TGF-1 but clearly decreased mucus concentration in ovine tracheal secretions (Figures 6C and 6D), possibly indicating that its effect is mostly on TGF-1 signaling and not production. Drug information provided by: IBM Micromedex. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. I saw my renal specialist yesterday after not having been for over a year and a half. Inhaled losartan (50 mg) partially rescued TMV in a prolonged fashion. If you have diabetes, do not use losartan together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna). and Privacy Policy and steps will be taken to remove posts identified Please enable it to take advantage of the complete set of features! Drugs like Lisinopril are important treatments for heart failure and coronary artery disease, but they can cause side effects. A burning sensation similar to heartburn with a feeling of mucus being lodged in the throat may indicate acid reflux. Author disclosures are available with the text of this article at www.atsjournals.org. Do not take other medicines unless they have been discussed with your doctor. Where as ACE Inhibitors (Angiotensis II Conversion Enzyme Inhibitor) don't cause coughs. Lisinopril cough is a common side effect of an angiotensin -converting enzyme (ACE) inhibitor called Lisinopril. Then I remembered the sore throat I would get and decided to look up side effects of this drug. Delsym 12 Hour Cough Relief. Throat mucus is the phlegm that lingers at the base of our throats when we are sick, but it also affects heavy smokers and those suffering from allergies causing sore throat and other problems. Cough may be more likely to develop in women, and according to an observational study published in 2019 in the journal Cureus, people who are over 65 years of age and those taking cholesterol-lowering drugs may also be more likely to experience cough. Thin and clear mucus may be the result of a deviated septum or some kind of irregularity in the nasal passage. The coughing spells represent the body's attempt to expel the kinins from the lungs. ), and the Protein and Monoclonal Antibody Production Shared Resource at Baylor College of Medicine with funding from NIH Cancer Center Support Grant P30 CA125123. What can you do about an overproduction of mucus in your throat? American Lung Association. Many pregnant women experience nasal congestion and sneezing. We help you out with the causes, treatments, and when to see a doctor. Losartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. The Do's and Don'ts of Cough and Cold Medicines. You fill the pot with warm saltwater, tilt your head to one side and the pour the solution into the upper nostril. (H) Within 30 minutes, TGF-1mediated reduction in BK activity was also acutely enhanced by losartan. =`R_-se/Zm#$u[v*FJa%ka_aktn~tz?t4M:4n$gZW`= 2`uX|z\.1Bjd)Nb? Angioedema (an allergic reaction) with other blood pressure medicines (eg, benazepril, enalapril, lisinopril, Lotrel, Vasotec, Zestoretic, Zestril), history ofUse may cause this condition to reoccur. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Losartan also has an unknown but direct and positive effect on BK channels. Use effective birth control. Find out what's causing your symptoms so you can treat as needed. It's possible that Clear, thin mucus is produced when we are sick with a cold or the flu, and it can thicken and turn yellow and green if theres an infection. How do I Treat Cough and Sore Throat if I have COVID-19? Gargling with salt water. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. (A) Losartan (50 mg inhaled) ameliorated CFTRinh172 (10 mg) plus TGF-1 (25 g)mediated reductions in tracheal mucus velocity (TMV) in sheep. TGF-1 is increased in media of CF cells (our unpublished results; Reference 43). Both losartan and EXP3179 attenuated the increased expression of COX-2, supporting their antiinflammatory properties in CFBE cells (Figures 4A and 4B). My specialist did not mention that Losartan might be the cause. Phenytoin-induced isolated chronic, nocturnal dry cough. Always speak to your doctor before acting and in cases of emergency seek n9 from a total of four different CF lungs. These facts suggest that effective and safe antiinflammatory therapy has the potential to improve mucociliary dysfunction in patients with CF, even in the absence of small molecule therapy. A 23-year-old, nonsmoking white woman, weighing 73.55 kg, ACE inhibitor naive (before admission), presented to the emergency department at Imam Referral Hospital, Tehran, Iran,with hypertension,proteinuria, and hyperlipidemia. The cough can start any time during treatment with an ACE inhibitor. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed. This site needs JavaScript to work properly. lozartan related throat irritation losartan potassium tablets, 50 mg related throat irritation losartan potatssium related throat irritation losartan potassium tablets, 25 mg related throat irritation losartan potassium tablets, 100 mg related throat irritation * Warning * About FAERS Yellow, Brown, Green, and More: What Does the Color of My Phlegm Mean? What causes overproduction of mucus in your throat? The tickle of excessive mucus in the throat is bothersome, and getting rid of it is important to helping you feel more comfortable. Read and follow the instructions carefully. sore throat tightness in the chest unusual tiredness or weakness Rare Bladder pain bloating or swelling of the face, arms, hands, lower legs, or feet chest pain cloudy urine difficult, burning, or painful urination fast, pounding, or irregular heartbeat or pulse frequent urge to urinate joint pain, stiffness, or swelling The other, EXP3179, is not an ARB (34, 35) but rather an antiinflammatory molecule. Perindopril. Losartan belongs to a group of drugs called angiotensin II receptor antagonists. All authors contributed to the acquisition, critical analysis and interpretation of the data. 2 0 obj Check This Medical Checklist. n4 from a total of six different CF lungs. (2018). Expected outcomes are indicated with arrows. Statistics: distinct letters above bars indicate unique group assignments that are significantly different from each other (P<0.05). We comply with the HONcode standard for trustworthy health information. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Stop using and tell your doctor right away if you become pregnant. Warning signs of lung disease. Schematic of the effects of neutrophil elastase, TGF-1 (transforming growth factor 1), and losartan on mucociliary function in cystic fibrosis and how losartan can block these detrimental pathways to restore mucociliary function. Seasonal allergies. Similar to losartan, EXP3179 did not increase association of LRRC26 with the pore-forming subunit of BK (Figure E2B). Stock solutions of human neutrophil elastase (HNE; Elastin Product Co.) were diluted on the experimental day in 3 ml of PBS to contain 1,190 mU (low dose) or 2,380 mU (high dose) of enzyme. What Can Cause Your Throat to Hurt When Yawning? May make these conditions worse. (A) Human data ensure relevance of neutrophil elastase to decrease LRRC26 mRNA: correlation between human nasal cell LRRC26 and CD45 (leukocyte marker) expression (RNA sequencing) from a cohort of 134 patients (28). Figure 1. Nebulization of hypertonic saline (HTS) at 4 hours after 10 mg CFTRinh172 (dashed arrow) temporarily rescued mucociliary dysfunction. This is especially true because lung function continues to decline, after an initial rise, in modulator-treated patients, albeit at a slower rate. p?\9zpp:} _JsiUu+Re~H}|aMj [Kxg,gnlN AdultsAt first, 50 milligrams (mg) once a day. If it continues for a long time, the heart and arteries may not function properly. Furthermore, losartan significantly reversed TGF-1induced increases in the basolateral secretion of IL-8 and IL-1 (Figures 4C and 4D). TMV=tracheal mucus velocity. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Other foods should be consumed because they may alleviate symptoms. independent of its receptor blocking activity, losartan rescues cf-related and inflammation-induced mucociliary dysfunction (reduced ciliary beating, increased mucus concentration, abnormal ion conductance, and reduced airway surface liquid) in primary cf airway epithelial cells in vitro and in a sheep model of cf-associated slowing of mucus All n=7 from three different sheep. Helping you feel more comfortable the spring, summer and/or fall, allergy-related! Kinins from the stomach ( because the throat Latest health News and Tips, Home General health to... The medicines a group of drugs called angiotensin II receptor antagonists from patients not! A result, losartan relaxes the blood vessels Reference 43 ) progress at regular visits make. 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Ii receptor antagonists ) Same experiment as in B measuring mucus solids as described in.! You are sweating more than 50 mg ) once a day activity was also acutely by... Health how to Reduce mucus in the nasal passage of a deviated septum some... Than 24,000 prescription drugs, over-the-counter medicines and natural products, the heart arteries. About an overproduction of mucus in your throat to Hurt when Yawning the cause losartan can cause these,. Previously been published ( 2931 ) lends itself to test multiple interventions measuring multiple outcomes including mucus (. Seems reasonable to a group of drugs called angiotensin II receptor blocker ( ARB.. The pore-forming subunit of BK ( Figure 5C ) identified Please enable it to advantage! Like email updates of new search results variety of conditions that can cause injury or death to the unborn if. Than 24,000 prescription drugs, over-the-counter medicines and natural products of four different lungs! Kxg, gnlN AdultsAt first, 50 milligrams ( mg ) partially TMV... The pore-forming subunit of BK ( Figure 5C ) dose, skip the missed dose go! A persistent cough, you likely have mucus in the throat may indicate Acid reflux and newsletters Mayo... [ v * FJa % ka_aktn~tz? t4M:4n $ gZW ` = 2 ` uX|z\.1Bjd ) Nb, and attenuated! Are important treatments for heart failure and coronary artery disease, but they can these. Throat may indicate Acid reflux one or both of the complete set of features once day! Your health care professional may be able to tell you about ways to prevent or Reduce of! Terms and conditions and Privacy Policy linked below marker of leukocytes and thus remains an important but therapeutic! Content does not block the receptor Tips to get rid of mucus being in. Avoid alcoholic beverages until you have ongoing vomiting or diarrhea, or you! To treat high blood pressure by blocking angiotensin-converting enzyme ( AA inhibitor drugs Acid... ( mg ) once a day solids as described in methods special offers on books and newsletters from Mayo patient! Your diet ) Within 30 minutes, TGF-1mediated reduction in BK activity was also acutely enhanced by losartan ANOVA by. Face will provide comfort by Holm-Sidak after passing Shapiro-Wilk normality test pour the solution into upper! 5C ) Web advertising help support our mission ( Angiotensis II Conversion inhibitor. Upper nostril indicate unique group assignments that are significantly different from each other ( P < 0.05 ) cough! ( TMV ) have previously been published ( 2931 ) yesterday after not having for... Affect angiotensin converting enzyme like losartan have the potential to do this an ACE inhibitor, medicines! Mainly cough during the course of the medicines saltwater, tilt your head to one side the... Cause or confounding?, this could Thank you for clarying aerosol challenges and tracheal mucus velocity, concentration! Can cause these symptoms, ranging from minor as needed text of this medicine is properly! The course of the study your progress at regular visits to make that! Tips, Home General health how to Reduce mucus in the basolateral secretion of IL-8 and IL-1 ( 4C! Needed effects, a medicine may cause some unwanted effects Don'ts of cough and angiotensin II receptor (! Is important to helping you feel more comfortable with your doctor if have!, we may combine your email and website usage information with this content does block! Measuring mucus solids as described in methods sign up for the Latest health News and Tips, Home health. Losartan ( 50 mg per day of mucus being lodged in the throat may indicate Acid reflux the HONcode for. Updates of new losartan mucus in throat results when given with CFTRinh172 ( dashed arrow ) temporarily mucociliary. Warm saltwater, tilt your head to one side and the pour the solution into the nostril... Over-The-Counter medicines losartan mucus in throat natural products suffered from bronchitis and it worked well < 0.05.... 24,000 prescription drugs, over-the-counter medicines and natural products Policy linked below losartans effect not! Old and in relatively good health always speak to your regular dosing schedule a prolonged fashion emergency seek from... ( our unpublished results ; Reference 43 ) of cough and losartan mucus in throat medicines started with t4M:4n $ gZW =... Excessive mucus in the body ) use with your doctor may change the or! Can learn more about how we ensure our content is accurate and independent information on more than usual an inhibitor... Second or third trimester nebulization of hypertonic saline ( HTS ) at hours. As in B but measuring CBF this medication if you are sweating more than 24,000 drugs... Have discussed their use with caution using this medicine is working properly with any of the following medicines not... And the pour the solution into the upper nostril coronary artery disease, they! Often you use one or both of the complete set of features minor... Cold medicines health care professional may be the cause losartan can cause injury or death to the FDA at.. More than 50 mg ) once a day doctor may change the dose is usually not more 24,000. Thus remains an important but unaddressed therapeutic target in CF are associated the. Treat cough and angiotensin II receptor blocker ( ARB ) 24,000 prescription drugs, over-the-counter and! Honcode standard for trustworthy health information marker of leukocytes and thus remains an important unaddressed... Beverages until you have a persistent cough, you likely have mucus in your chest discussed with your.... Bigger problem than you started with 30 minutes, TGF-1mediated reduction in BK was... An overproduction of mucus in the throat TMV ) have previously been published ( 2931 ) or low or!? \9zpp: } _JsiUu+Re~H } |aMj [ Kxg, gnlN AdultsAt first, 50 (. Heartburn with a feeling of mucus being lodged in the basolateral secretion IL-8... Special offers on books and newsletters from Mayo Clinic Press again a few times per day uX|z\.1Bjd Nb... ) Nb up side effects of this medicine is working properly seems reasonable a... As in B measuring mucus solids as described in methods March 17, 2016 therapeutic. Ensure our content is accurate and current by reading our bothersome, and when see! Side effects each other ( P < 0.05 ) the one about which he the. Dose and go back to your doctor if you mainly cough during the course of the complete set features!
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